Serum levels of glucose (Glu), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), superoxide dismutase (SOD), serum creatinine (SCr), SUA, hs-CRP in fasting blood samples were measured by automated biochemical Analyzer 5800 (BECKMAN) or 7600 (HITACHI). The study protocol was approved by the Institutional Review Boards of the Sun Yat-sen Memorial Hospital and waived the need for informed consent and conducted in accordance with the principles embodied in the Declaration of Helsinki (2013). Those with various diseases and abnormal medical laboratory tests such as eGFR less than 60 ml/min/1.73m 2 were excluded from this study.

As described previously, the population enrolled into this study included the healthy subjects aged 18–89 years old without evidence of acute infection, cardiovascular disease, chronic kidney disease, cancer, diabetes, gout, obstructive pulmonary disease and Alzheimer’s disease based on the previous medical record in Sun Yat-sen Memorial Hospital. This was a retrospective study in the healthy Chinese population who underwent routine health examination carried out between April 1st, 2009 and May 1st, 2017 at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. The link between hs-CRP and these factors in the healthy population remains unknown, which was also analyzed in this study. In addition, although many inflammatory mediators including dyslipidemia, insulin resistance, oxidative stress, and serum uric acid (SUA) have also been shown to contribute to high levels of serum hs-CRP under various disease conditions. However, there is still a lack of evidence for the relationship between the baseline levels of hs-CRP and the ageing progress in general healthy population, which was investigated in this study. Many studies have shown that elevated levels of serum hs-CRP are associated with ageing and ageing-related diseases including cardiovascular disease (CVD), hypertension, diabetes mellitus, and kidney disorders. CRP, an acute phase protein, is primarily produced and secreted by the liver in response to IL-6.Serum levels of CRP can be measured by a high sensitivity immunoturbidometric assay termed high-sensitive CRP (hs-CRP). Many inflammatory effector molecules and biomarkers, especially C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), have been considered as important factors associated with ageing, ageing-related diseases or disability. Therefore, disentangling age-related low grade inflammation may slow or delay ageing process. Increasing evidence shows that inflammation is one of the key mechanisms associated with many ageing-related diseases, including cancer, atherosclerosis, hypertension, diabetes mellitus, ischemic heart disease, cirrhosis, Alzheimer’s disease and other dementias and chronic diseases. Thus, serum levels of hs-CRP may be an indicator associated with ageing in healthy Chinese population.Īgeing is a natural phenomenon characterized by gradual deterioration of the body structure and function with important social, public health, and economic implications. In addition, elevated serum levels of hs-CRP are also associated with increased SUA but decreased HDL-c and SOD.

Conclusionsīaseline levels of serum hs-CRP are increased with ageing and are significantly higher in male than female healthy population. Correlation analysis also revealed that serum levels of hs-CRP positively correlated with age and SUA, but inversely correlated with serum levels of HDL-c and SOD (all P < 0.05). Interestingly, levels of serum hs-CRP were significantly higher in male than female population (1.24 vs 1.07mg/L, P < 0.001). In total of 6060 healthy people, serum levels of hs-CRP were significantly increased with ageing ( P < 0.05), particularly in those with age over 45-year-old (1.31 vs 1.05mg/L, P < 0.001). Serum levels of high sensitive C-reactive protein (hs-CRP), glucose (Glu), triglyceride (TG), cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), superoxide dismutase (SOD), serum creatinine (SCr), serum uric acid (SUA) were measured in 6060healthy subjects (3672 male and 2388 female, mean age:45.9 years) who received routine physical examination at Sun Yat-sen Memorial Hospital, Guangzhou, China. However, serum levels of CRP in the healthy ageing population remained unclear, which was investigated in the present study. Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases.

Highc reactive protein quant